Skip to product information
phyto nature e² regenerating daily exosome leave-on treatment
1/15

phyto nature e² regenerating daily exosome leave-on treatment

renew + resurface

£148.00

size: 100ml

100% money back guarantee

100% money back guarantee

within 30 days

Order before 3PM

Order before 3PM

for next day delivery

Recommended for:

  • visible signs of ageing
  • dullness or uneven texture
  • fine lines and wrinkles
  • loss of firmness and elasticity - without wanting injectables or invasive treatments.

Daily exosome leave-on visibly smooths and supports skin regeneration.

Formulated with next-gen exosomes and enzymes, this lightweight, silky leave-on helps reawaken skin’s natural surface renewal process, improving natural regeneration by 86%.*

Exfoliating enzymes help clear away dull surface cells, revealing smoother, brighter skin. A regenerative exosome blend acts in multiple layers of skin’s surface, visibly diminishing fine lines and wrinkles. In an independent clinical study, fine lines and wrinkles were visibly diminished in 2 weeks.**

Clinically proven results - Independent trials

  • visibly reduces signs of skin ageing in 2 weeks*
  • skin looks smoother, brighter and more refined
  • texture feels improved with continued use
*Independent clinical study. Results at 2 weeks, based on a reduction in visible signs of skin aging with 32 subjects, 2 applications/day. with 32 subjects, twice-daily use.
**Versus untreated skin. Based on in vitro testing.

dont just take our word for it

Benefits
  • Regenerative Exosome Blend visibly diminishes the appearance of fine lines and wrinkles
  • Accelerates skin’s natural renewal process
  • Resurfaces to reveal brighter, smoother skin every day
  • phyto nature e2 ​with next-gen exosomes ​gives 6 years back*

*Results at 8 weeks, based on a reduction in visible signs of skin aging in an independent clinical study with 32 subjects, 2 applications/day.

How to use

Step 1: Cleanse
Start with PreCleanse to remove makeup, SPF and daily buildup. Follow with Special Cleansing Gel to gently cleanse without stripping skin.

Optional: Use Daily Microfoliant after cleansing if part of your routine.

Step 2: Renew with Phyto Nature E²
Apply Phyto Nature E² to clean skin as your first leave-on step. Allow it to absorb fully - for best results use morning and night.

Step 3: Layer serums and moisturisers
Once absorbed, layer your usual serums and moisturiser. Phyto Nature E² works seamlessly with other treatments.
Pro Tip: Follow with Phyto Nature Firming Serum and Phyto Nature Oxygen Cream for enhanced results.

Step 4: Protect (daytime only)
Finish with a broad-spectrum SPF, such as Dynamic Skin Recovery SPF50. Apply generously as the final step in your routine.

Use only as directed. Avoid contact with eyes. If irritation or persistent redness develops, discontinue use and consult a physician.

Ingredients

Inside the formula

Regenerative Exosome Blend
Plant-derived, vegan exosomes help support regeneration across multiple layers of skin’s surface - visibly reducing the appearance of fine lines and wrinkles.

Pumpkin Enzyme
Gently exfoliates by breaking down the bonds between dead skin cells, revealing brighter, smoother-looking skin daily.

Botanical Renewal Complex
With Phyto Glycogen and Prickly Pear to help boost skin’s natural exfoliation and smoothness.

Bio-Fermented Acetyl Glucosamine
Helps hydrate skin and provide antioxidant protection.

Key Ingredients:

  • Pumpkin enzyme: Exfoliates to reveal brighter, smoother skin daily
  • Regenerative exosome blend: Acts in multiple layers of skin’s surface, visibly diminishing fine lines and wrinkles
  • Botanical blend with phyto glycogen + prickly pear: Visibly brightens and smooths
  • Bio-fermented acetyl glucosamine: Hydrates and provides antioxidant protection

Water/Aqua/Eau, Lactobacillus/Pumpkin Ferment Extract, Propanediol, Lactococcus Ferment Lysate, Ethoxydiglycol, Hydrolyzed Soy Protein, Acetyl Glucosamine, Hydroxyacetophenone, Lactic Acid, Hydrolyzed Opuntia Ficus-Indica Flower Extract, Helianthus Annuus (Sunflower) Seed Oil, Citrus Aurantium Bergamia (Bergamot) Fruit Oil, Citrus Limon (Lemon) Peel Oil, Citrus Aurantium Dulcis (Orange) Peel Oil, Salvia Sclarea (Clary) Oil, Pyrus Malus (Apple) Fruit Extract, Viola Odorata Leaf Extract, Acacia Senegal Gum Extract, Curcuma Longa (Turmeric) Root Extract, Mucor Miehei Extract, Lavandula Spica (Lavender) Flower/Leaf/Stem Extract, Rosmarinus Officinalis (Rosemary) Leaf Oil, Litsea Cubeba Fruit Oil, Camellia Japonica Flower Extract, Glycerin, Mentha Piperita (Peppermint) Oil, Butylene Glycol, Lactobacillus Ferment, Glycogen, Urea, Caprylyl Glycol, Phospholipids, Glucosamine HCl, Xanthan Gum, PEG-40 Hydrogenated Castor Oil, 1,2-Hexanediol, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Citric Acid, Polyacrylate Crosspolymer-6, Acacia Senegal Gum, Sodium Chloride, Sodium Citrate, Disodium EDTA, Sodium Benzoate, Potassium Sorbate, Limonene, Linalool, Citral.

Dermalogica is dedicated to maintaining the accuracy of the ingredient lists on this website. However, because ingredients are subject to change, we cannot guarantee that these lists are complete, up-to-date and/or error-free. For an accurate listing of ingredients in each product, please refer to your product packaging.

Perfect pairs

Phyto Nature Oxygen Cream

Breathe new life into ageing skin

Daily firming and lifting liquid moisturiser revitalises skin with hydrating, oxygen-optimising phytoactives - breathing new life into ageing skin.

Light as air, liquid moisturiser utilises rare plant actives to firm, revitalise and plump skin reducing the signs of premature skin ageing. Clinically proven to give 4 years back* with skin looking firmer and more lifted after 1 week. Ligustrum Lucidum seed, Glycogen, and Nasturtium Flower optimise skin’s oxygenation process to boost luminosity and radiance. Adaptogenic Astragalus and Electric Daisy Flower smooth and tighten whilst Squalane and Luffa Root firm and hydrate. It also contains antioxidant-rich Rose of Winter to soothe and boost skin’s resilience. Skin is left looking luminous and revitalised.

shop now

Exo Booster Microneedling

clinically proven to enhance post procedure results

Experience an ultimate fusion of cutting-edge technologies designed to amplify the delivery of potent exosomes, breathing new life into your skin.

Leave with a 7-day professional dose of booster serum to powerfully firm, smooth and rejuvenate your complexion like never before. This bi-phase professional treatment takes advanced services to the next level, Lactobacillus Exosomes deliver encapsulated bioactives segregated by living cells to combine with restorative Pro Resolution Technology, helping to support natural cell renewal and boost skin’s vitality.

Book Now
Sustainability

Materials: Bottle: Glass, Pump/cap: Mixed material, Carton: Paper

What’s Recyclable: The bottle of this Dermalogica product is fully recyclable. The paper used in this carton is recyclable and comes from FSC certified responsibly managed forests.

How to Recycle: Ensure bottle is as empty as possible and place in recycling bin. Dispose of pump and cap in waste bin. Place carton in its recycling bin.

Recycling is subject to local policies and facilities.

Learn more about Dermalogica's sustainability efforts here

how this breakthrough ingredient supports skin regeneration

Frequently asked questions

What is Phyto Nature E² Exosome Exfoliant?

Phyto Nature E² is a daily leave-on exfoliating treatment designed to resurface dull surface cells while supporting a smoother, brighter, more youthful-looking complexion over time. It combines an exfoliating enzyme system with an exosome blend to support ongoing skin renewal in a single step.

Can I use this if I'm pregnant or breastfeeding?

We always recommend checking with your GP, midwife or healthcare professional before introducing new skincare during pregnancy or breastfeeding. Phyto
Nature E² does not contain retinoids, but individual guidance is best.

How much product should I use per application?

Use one to two pumps for the face and neck. Apply a thin, even layer and allow it to absorb fully before layering on other products.

Is it a serum or an exfoliant?

It’s best described as a serum-textured, leave-on exfoliant. The texture is lightweight and layerable like a serum, but the purpose is daily resurfacing (exfoliation) plus renewal support—so you don’t rinse it off like a scrub or wash-off peel.

Are the exosomes in this product plant-based?

Yes, the exosomes in Phyto Nature E² are plant-based because these are not derived from human or animal cells.

What makes this different from AHA/BHA chemical exfoliants?

Phyto Nature E² delivers daily resurfacing using an enzyme-based exfoliating approach. While AHA and BHA exfoliants target concerns like breakouts or congestion. Phyto Nature E² supports natural cell turnover for radiance + visible skin ageing concerns.

Does it contain acids as well as enzymes?

The formula includes an exfoliating enzyme system and also contains lactic acid among its ingredients. How it performs can depend on the overall formulation and your skin tolerance—so if you’re sensitive or new to leave-on exfoliants, introduce it gradually.

How often should I use it?

We recommend using Phyto Nature E² twice daily (morning and evening, on clean skin). If your skin is new to leave-on exfoliants or tends to be reactive, start slow. Begin with once daily or every other day, and build up as your skin adapts.

Where does it go in my routine?

Apply to clean skin as the first step after cleansing. Allow it to absorb fully, then follow with the rest of your routine (for example: hydrating serum, moisturiser, and SPF in the morning). Because it’s a leave-on exfoliant, you don’t rinse it off.

Can I layer it with other products?

Yes—its serum-like texture is designed to layer easily. If you use stronger actives (retinoids, exfoliating acids, or high-strength vitamin C), consider alternating usage (for example, on different nights) or reduce frequency to avoid over-exfoliation.

Can I use it with retinol?

Many people can, but it depends on skin tolerance. If you’re using retinol, start by alternating nights (retinol one night, Phyto Nature E² the next) and prioritise moisturiser/barrier support. If you experience persistent stinging, redness or peeling, reduce frequency.

Can I use Phyto Nature E² with vitamin C or acids?

Yes. Phyto Nature E² can be layered with vitamin C serums.
If using stronger exfoliating acids, consider alternating use or monitoring
your skin’s response to avoid over-exfoliation.

Should I still exfoliate if I’m using this daily? Can I use Daily Microfoliant or Superfoliant too?

If your skin is used to regular exfoliation, you can still use Daily Microfoliant or Daily Superfoliant. Just dial back to 2–3 times per week, and pay attention to how your skin feels.

Which products should I avoid when using this product?

Avoid layering Phyto Nature E² at the same time as strong professional-style exfoliants, such as Liquid Peelfoliant. If using these
products, alternate days or consult a skin therapist for personalised advice.

Is it suitable for sensitive skin?

Those with sensitive skin should patch test first and introduce slowly. Even gentle daily exfoliation can be too much for some skin barriers, especially if you’re already using retinoids, acids, or if your skin is compromised.

Will it cause purging or breakouts?

Any exfoliant can temporarily increase turnover, which may bring existing congestion to the surface. This should be mild and short-lived. If you experience painful breakouts, swelling, or ongoing irritation, stop and reassess your routine (you may be over-exfoliating or reacting to an ingredient).

When should I expect to see results?

Skin results always vary, but you’ll see the best outcome with consistent use and daily SPF to protect your progress. Boost results by layering with Phyto Nature Firming Serum and Phyto Nature Oxygen Cream.

Why is it recommended for GLP-1 users?

Some people using GLP-1 medications say their skin feels drier, looks duller, or shows texture changes—often because overall routines and hydration can shift. A gentle, consistent routine focused on hydration, barrier support and mild resurfacing may help the appearance of radiance and texture. This is cosmetic skincare guidance only; for medical concerns or side effects, speak to a healthcare professional.

Does it contain fragrance or essential oils?

Phyto Nature E² includes select botanical oils and naturally occurring fragrance components such as limonene, linalool, and citral. We suggest reaching out to our LIVE Chat team with Professional Skin Therapists ready to assist with any concerns.

customer reviews & questions

a skin therapist would recommend